Assay Detail
Functional
CHEMBL989923
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Antitrypanosomal activity against Leptomonas seymouri
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leptomonas seymouri |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Studies of trypanocidal (inhibitory) power of naphthoquinones: evaluation of quantum chemical molecular descriptors for structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.08 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197655 | MANSONONE F | — | 1 | 7.00 |
| CHEMBL353562 | — | — | 1 | 6.52 |
| CHEMBL362672 | MANSONONE E | — | 1 | 6.40 |
| CHEMBL522424 | — | — | 1 | 6.40 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.40 |
| CHEMBL176758 | — | — | 1 | 6.16 |
| CHEMBL508283 | — | — | 1 | 5.40 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 5.39 |
| CHEMBL449890 | MANSONONE A | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197655 | MANSONONE F | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL353562 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL362672 | MANSONONE E | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL522424 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL176758 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL508283 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL449890 | MANSONONE A | IC50 | = | 8500.0 | nM | 5.07 |