Compound Detail
CHEMBL522424
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Basic Information
| ChEMBL ID | CHEMBL522424 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RTDZBRHYOPGZAM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
1
Known Names
Molecular Properties
276.7
MW (Da)
3.41
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.68
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leptomonas seymouri CHEMBL612917 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Crithidia fasciculata CHEMBL612650 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leptomonas seymouri | IC50 | = | 400.0 | nM | 6.4 | Antitrypanosomal activity against Leptomonas seymouri | 18276039 |
| Crithidia fasciculata | IC50 | = | 800.0 | nM | 6.1 | Antitrypanosomal activity against Crithidia fasciculata | 18276039 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18276039 | 10.1016/j.ejmech.2007.12.023 | No relevant target | 2 |
| 18276039 | 10.1016/j.ejmech.2007.12.023 | Leptomonas seymouri | 1 |
| 18276039 | 10.1016/j.ejmech.2007.12.023 | Crithidia fasciculata | 1 |
Data from ChEMBL 36 via Core Engine