Compound Detail
CHEMBL1769
PROPOXYCAINE HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1769 |
| Name | PROPOXYCAINE HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GITPCGSPKUQZTE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL1195 |
| Active Moiety | CHEMBL1195 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
3
Known Names
1
Mechanisms
Molecular Properties
294.4
MW (Da)
2.56
ALogP
5
HBA
1
HBD
64.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sodium channel alpha subunit blocker | BLOCKER | Sodium channel alpha subunit | ✓ | ✓ |
Activity Summary
IC50 2 meas. best 4.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.62 | 4.62 | 23988.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 24000.0 | nM | 4.62 | Displacement of [3H]-BTX-B from neuronal voltage-gated sodium channel in rat cer... | 19346132 |
| Unchecked | IC50 | = | 23988.33 | nM | 4.62 | Displacement of [3H]-BTX-B from neuronal voltage-gated sodium channel in rat cer... | 19346132 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19346132 | 10.1016/j.bmc.2008.10.031 | Unchecked | 2 |
| 19346132 | 10.1016/j.bmc.2008.10.031 | No relevant target | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine