Compound Detail
CHEMBL1779686
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Basic Information
| ChEMBL ID | CHEMBL1779686 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIOIOAYAPNNFPT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
380.8
MW (Da)
5.86
ALogP
2
HBA
3
HBD
61.4
PSA (Ų)
0.52
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL5102 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 12.0 | nM | 7.92 | Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin a... | 21531136 |
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 13.0 | nM | 7.89 | Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin... | 21531136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21531136 | 10.1016/j.bmcl.2011.04.013 | Transient receptor potential cation channel subfamily V member 1 | 2 |
Data from ChEMBL 36 via Core Engine