Compound Detail

CHEMBL17879

MARALIXIBAT CHLORIDE

💊 Approved Drug

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💊 Approved Drug

CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OCc3ccc(C[N+]45CCN(CC4)CC5)cc3)cc2)[C@H]1O.[Cl-]

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL17879
Name	MARALIXIBAT CHLORIDE
Phase	Approved
Structure Type	MOL
InChI Key	POMVPJBWDDJCMP-RUKDTIIFSA-M
Therapeutic	✓ Yes
Parent Compound	CHEMBL363392
Active Moiety	CHEMBL363392

Known Names

Chlorure de maralixibat Cloruro de maralixibat Livmarli Lopixibat chloride LUM-001 LUM001 Maralixibat chloride

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

675.0

MW (Da)

6.62

ALogP

HBA

HBD

70.1

PSA (Å²)

0.21

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	2021
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Oral

USAN Stem	-ixibat
USAN Year	2016

Extended Properties

Molecular Formula	C40H56ClN3O4S
MW	710.42
Aromatic Rings	3
Heavy Atoms	48
NP-Likeness	-0.25

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Ileal bile acid transporter inhibitor	INHIBITOR	Ileal sodium/bile acid cotransporter	✓	✓

Indications

Alagille Syndrome Pruritus Cholangitis, Sclerosing Liver Cirrhosis, Biliary

ATC Classification

A05AX04

maralixibat chloride

Level 1: ALIMENTARY TRACT AND METABOLISM

Level 2: BILE AND LIVER THERAPY

Activity Summary

IC50 1 meas. best 6.05

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Ileal sodium/bile acid cotransporter CHEMBL2778	IC50	6.05	6.05	890.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Ileal sodium/bile acid cotransporter	IC50	=	890.0	nM	6.05	In vitro Inhibition of apical sodium-dependent bile acid transporter by measurin...	14980661

Literature References

PubMed	DOI	Target Context	# Activities
14980661	10.1016/j.bmcl.2003.12.063	Ileal sodium/bile acid cotransporter	1

Data from ChEMBL 36 via Core Engine