Compound Detail
CHEMBL180025
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL180025 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LJXYQIVEZHXDCA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
387.5
MW (Da)
5.76
ALogP
5
HBA
0
HBD
57.7
PSA (Ų)
0.54
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.35 | 7.35 | 44.7 | 1 |
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | IC50 | 7.3 | 7.3 | 50.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 44.67 | nM | 7.35 | Displacement of [125I]o-CRF from recombinant human CRF receptors expressed in Ch... | 15946843 |
| Corticotropin-releasing factor receptor 1 | IC50 | = | 50.12 | nM | 7.3 | Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO ... | 17629700 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15946843 | 10.1016/j.bmcl.2005.05.040 | Unchecked | 1 |
| 17629700 | 10.1016/j.bmcl.2007.06.077 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine