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Compound Detail

CHEMBL1800660

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CCCCN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1

Basic Information

ChEMBL ID CHEMBL1800660
Phase Preclinical
Structure Type MOL
InChI Key SEPMRQHFLHXBBG-QFIPXVFZSA-N
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names

Molecular Properties

501.6
MW (Da)
3.20
ALogP
7
HBA
4
HBD
114.9
PSA (Ų)
0.24
QED
1
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H35N3O5S
MW 501.65
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.61

Activity Summary

EC50 1 meas. best 9.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.1 9.1 0.8 1

Pharmacokinetic Data

Parameter Value Units Species
CL 150.0 uL.min-1.(10^6cells)-1 Rattus norvegicus
CL 150.0 mL.min-1.g-1 Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21652207 10.1016/j.bmcl.2011.04.135 Beta-2 adrenergic receptor 2
- 10.6019/CHEMBL3301361 ADMET 2
- 10.6019/CHEMBL3301361 No relevant target 1

Data from ChEMBL 36 via Core Engine