Compound Detail
CHEMBL1819500
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Basic Information
| ChEMBL ID | CHEMBL1819500 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OMXIBLNDNZLNPO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
468.6
MW (Da)
5.07
ALogP
4
HBA
1
HBD
50.8
PSA (Ų)
0.59
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-dependent T-type calcium channel subunit alpha-1G CHEMBL4641 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-dependent T-type calcium channel subunit alpha-1G | IC50 | = | 320.0 | nM | 6.5 | Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibit... | 21875808 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21875808 | 10.1016/j.bmc.2011.07.030 | Voltage-dependent T-type calcium channel subunit alpha-1G | 1 |
| 21875808 | 10.1016/j.bmc.2011.07.030 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine