Compound Detail
CHEMBL1821982
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Basic Information
| ChEMBL ID | CHEMBL1821982 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JKBTZEMTHJZUOH-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1852498 |
| Active Moiety | CHEMBL1852498 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
327.4
MW (Da)
4.41
ALogP
2
HBA
1
HBD
43.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aminopeptidase N CHEMBL2590 | Ki | 7.4 | 7.4 | 40.0 | 1 |
| Cytosol aminopeptidase CHEMBL1671610 | Ki | 4.3 | 4.3 | 50000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | Ki | = | 40.0 | nM | 7.4 | Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate aft... | 21843945 |
| Cytosol aminopeptidase | Ki | = | 50000.0 | nM | 4.3 | Inhibition of bovine kidney cytosolic leucine aminopeptidase using L-leucine-p-n... | 21843945 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21843945 | 10.1016/j.bmc.2011.06.089 | Aminopeptidase N | 1 |
| 21843945 | 10.1016/j.bmc.2011.06.089 | Cytosol aminopeptidase | 1 |
| 21843945 | 10.1016/j.bmc.2011.06.089 | Bacterial leucyl aminopeptidase | 1 |
Data from ChEMBL 36 via Core Engine