Compound Detail
CHEMBL1825133
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Basic Information
| ChEMBL ID | CHEMBL1825133 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZLWXGIXHQBMQNJ-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
493.4
MW (Da)
3.53
ALogP
7
HBA
2
HBD
112.3
PSA (Ų)
0.46
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.28
Ki 1 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 7.62 | 7.62 | 23.7 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 7.28 | 7.28 | 52.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | Ki | = | 23.7 | nM | 7.62 | Binding affinity to human recombinant c-MET assessed as inhibition of autophosph... | 21812414 |
| Hepatocyte growth factor receptor | IC50 | = | 52.6 | nM | 7.28 | Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as... | 21812414 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21812414 | 10.1021/jm2007613 | Hepatocyte growth factor receptor | 2 |
| 21812414 | 10.1021/jm2007613 | Liver microsomes | 1 |
Data from ChEMBL 36 via Core Engine