Compound Detail
CHEMBL182595
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Basic Information
| ChEMBL ID | CHEMBL182595 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MBANSLYUPGYBGU-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
352.5
MW (Da)
3.93
ALogP
6
HBA
1
HBD
72.3
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 7.07 | 7.07 | 85.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 85.0 | nM | 7.07 | Binding affinity for recombinant human CRF1 receptor | 15225703 |
| Corticotropin-releasing factor receptor 1 | Ki | = | 85.0 | nM | 7.07 | Inhibition of [125I]o-CRF binding to CHO cells expressing human CRF1 receptor | 15341493 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15225703 | 10.1016/j.bmcl.2004.05.056 | Corticotropin-releasing factor receptor 1 | 1 |
| 15341493 | 10.1021/jm040058e | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine