Compound Detail
CHEMBL1830639
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Basic Information
| ChEMBL ID | CHEMBL1830639 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZARYAJCIFUJCDR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
512.6
MW (Da)
1.59
ALogP
11
HBA
1
HBD
109.5
PSA (Ų)
0.50
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 7.1 | 7.1 | 79.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 79.0 | nM | 7.1 | Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]... | 21871695 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21871695 | 10.1016/j.ejmech.2011.07.054 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 21871695 | 10.1016/j.ejmech.2011.07.054 | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
| 21871695 | 10.1016/j.ejmech.2011.07.054 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 21871695 | 10.1016/j.ejmech.2011.07.054 | Blood | 1 |
Data from ChEMBL 36 via Core Engine