Compound Detail
CHEMBL183290
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Basic Information
| ChEMBL ID | CHEMBL183290 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLJYSPZUWPQJRS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
461.5
MW (Da)
6.59
ALogP
4
HBA
0
HBD
50.8
PSA (Ų)
0.33
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 8.09 | 8.09 | 8.1 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.54 | 7.54 | 29.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 8.1 | nM | 8.09 | Inhibition of Bovine farnesyl transferase | 15582430 |
| Unchecked | IC50 | = | 29.0 | nM | 7.54 | Inhibition of FTase | 17236767 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15582430 | 10.1016/j.bmcl.2004.10.014 | Protein farnesyltransferase | 1 |
| 17236767 | 10.1016/j.bmcl.2006.12.087 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine