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Compound Detail

CHEMBL183491

SODIUM FORMATE
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Basic Information

ChEMBL ID CHEMBL183491
Name SODIUM FORMATE
Phase Preclinical
Structure Type MOL
InChI Key HLBBKKJFGFRGMU-UHFFFAOYSA-M

Known Names

E237
2
Targets
12
Activities
1
Assay Types
0
PK Parameters
17
Publications
1
Known Names

Molecular Properties

68.0
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula CHNaO2
MW 68.01

Activity Summary

Ki 12 meas. best 4.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase
CHEMBL5337
 Ki 4.46 4.46 35100.0 1
Unchecked
CHEMBL612545
 Ki 4.27 4.27 53500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Carbonic anhydrase Ki = 35100.0 nM 4.46 Inhibition of Candida albicans Nce103 19297172
Unchecked Ki = 53500.0 nM 4.27 Inhibition of Cryptococcus neoformans Can2 19297172

Literature References

PubMed DOI Target Context # Activities
19278021 10.1002/ps.1747 Unchecked 2
21402476 10.1016/j.bmcl.2011.02.057 Unchecked 2
15501037 10.1016/j.bmcl.2004.09.064 Carbonic anhydrase V 1
11101640 10.1111/j.1469-7793.2000.00285.x Monocarboxylate transporter 4 1
21402476 10.1016/j.bmcl.2011.02.057 Carbonic anhydrase 1 1
19297172 10.1016/j.bmc.2009.02.058 Carbonic anhydrase 1
19297172 10.1016/j.bmc.2009.02.058 Unchecked 1
19297172 10.1016/j.bmc.2009.02.058 Carbonic anhydrase 2 1
15501037 10.1016/j.bmcl.2004.09.064 Carbonic anhydrase 9 1
15664815 10.1016/j.bmcl.2004.11.057 Carbonic anhydrase 1 1
15501037 10.1016/j.bmcl.2004.09.064 Carbonic anhydrase 4 1
15501037 10.1016/j.bmcl.2004.09.064 Carbonic anhydrase 2 1
15501037 10.1016/j.bmcl.2004.09.064 Carbonic anhydrase 1 1
15664815 10.1016/j.bmcl.2004.11.057 Carbonic anhydrase 9 1
15664815 10.1016/j.bmcl.2004.11.057 Carbonic anhydrase 5A, mitochondrial 1
15664815 10.1016/j.bmcl.2004.11.057 Carbonic anhydrase 4 1
15664815 10.1016/j.bmcl.2004.11.057 Carbonic anhydrase 2 1

Data from ChEMBL 36 via Core Engine