Compound Detail
CHEMBL185006
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Basic Information
| ChEMBL ID | CHEMBL185006 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MOSIZFCDSISEBV-CDTUYSNOSA-P |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
370.5
MW (Da)
3.89
ALogP
2
HBA
2
HBD
31.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel CHEMBL2096673 | IC50 | 6.42 | 6.31 | 380.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel | IC50 | = | 380.0 | nM | 6.42 | Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons ... | 15261276 |
| Small conductance calcium-activated potassium channel | IC50 | = | 630.0 | nM | 6.2 | Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons ... | 15261276 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15261276 | 10.1016/j.bmcl.2004.06.011 | Small conductance calcium-activated potassium channel | 2 |
Data from ChEMBL 36 via Core Engine