Compound Detail
CHEMBL185997
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL185997 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UUCCOLYYQJSQJL-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
439.0
MW (Da)
4.36
ALogP
5
HBA
1
HBD
57.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 7.66 | 7.59 | 22.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 22.0 | nM | 7.66 | Displacement of 150p M [125I]MCH from human MCH1R expressed in CHO-K1 cells | 16134937 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells | 15267235 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15267235 | 10.1021/jm040762v | Melanin-concentrating hormone receptor 1 | 1 |
| 16134937 | 10.1021/jm050103y | Melanin-concentrating hormone receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine