Assay Detail
Binding
CHEMBL830966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.80 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184291 | — | — | 1 | 8.30 |
| CHEMBL178707 | — | — | 1 | 8.26 |
| CHEMBL187756 | — | — | 1 | 8.00 |
| CHEMBL185997 | — | — | 1 | 7.52 |
| CHEMBL184717 | — | — | 1 | 7.30 |
| CHEMBL184860 | — | — | 1 | 6.64 |
| CHEMBL189083 | — | — | 1 | 6.60 |
| CHEMBL263702 | — | — | 1 | 6.52 |
| CHEMBL186077 | — | — | 1 | 6.14 |
| CHEMBL189653 | — | — | 1 | 6.10 |
| CHEMBL187430 | — | — | 1 | 5.18 |
| CHEMBL186842 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184291 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL178707 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL187756 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL185997 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL184717 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL184860 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL189083 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL263702 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL186077 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL189653 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL187430 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL186842 | — | IC50 | = | 8200.0 | nM | 5.09 |