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Compound Detail

CHEMBL186196

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CCOc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12

Basic Information

ChEMBL ID CHEMBL186196
Phase Preclinical
Structure Type MOL
InChI Key HPWOVHXZFXEIOB-VGSWGCGISA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

499.7
MW (Da)
4.68
ALogP
6
HBA
4
HBD
103.5
PSA (Ų)
0.24
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H29N3O4S2
MW 499.66
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness -1.30

Activity Summary

EC50 2 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 9.0 9.0 1.0 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.11 8.11 7.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15546707 10.1016/j.bmcl.2004.10.035 Beta-1 adrenergic receptor 2
15546707 10.1016/j.bmcl.2004.10.035 Beta-2 adrenergic receptor 2
15546707 10.1016/j.bmcl.2004.10.035 Beta-3 adrenergic receptor 2

Data from ChEMBL 36 via Core Engine