Compound Detail
CHEMBL186296
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Basic Information
| ChEMBL ID | CHEMBL186296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SKBFKQGIZHTDGM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
370.5
MW (Da)
2.20
ALogP
5
HBA
2
HBD
88.7
PSA (Ų)
0.40
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis C virus CHEMBL379 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
| Internal ribosome entry site (IRES) CHEMBL612412 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis C virus | IC50 | = | 2100.0 | nM | 5.68 | In vitro inhibitory concentration against hepatitis C virus internal ribosome en... | 15380215 |
| Internal ribosome entry site (IRES) | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of HCV IRES RNA by luciferase reporter gene assay | 38784459 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15380215 | 10.1016/j.bmcl.2004.07.066 | Hepatitis C virus | 2 |
| 38784459 | 10.1039/d3md00696d | Internal ribosome entry site (IRES) | 1 |
Data from ChEMBL 36 via Core Engine