Assay Detail
Functional
CHEMBL824904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against hepatitis C virus internal ribosome entry site (HCV-IRES) translation
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Biaryl guanidine inhibitors of in vitro HCV-IRES activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 4.55 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186296 | — | — | 1 | 5.68 |
| CHEMBL363014 | — | — | 1 | 5.38 |
| CHEMBL366110 | — | — | 1 | 5.12 |
| CHEMBL184322 | — | — | 1 | 5.09 |
| CHEMBL363221 | — | — | 1 | 5.02 |
| CHEMBL184097 | — | — | 1 | 5.01 |
| CHEMBL185377 | — | — | 1 | 5.00 |
| CHEMBL186556 | — | — | 1 | 4.92 |
| CHEMBL187011 | — | — | 1 | 4.89 |
| CHEMBL187036 | — | — | 1 | 4.89 |
| CHEMBL184261 | — | — | 1 | 4.82 |
| CHEMBL185422 | — | — | 1 | 4.80 |
| CHEMBL184208 | — | — | 1 | 4.72 |
| CHEMBL365897 | — | — | 1 | 4.68 |
| CHEMBL184675 | — | — | 1 | 4.64 |
| CHEMBL187070 | — | — | 1 | 4.64 |
| CHEMBL434543 | — | — | 1 | 4.64 |
| CHEMBL187026 | — | — | 1 | 4.64 |
| CHEMBL185122 | — | — | 1 | 4.64 |
| CHEMBL185303 | — | — | 1 | 4.62 |
| CHEMBL360433 | — | — | 1 | 4.60 |
| CHEMBL184517 | — | — | 1 | 4.60 |
| CHEMBL186587 | — | — | 1 | 4.58 |
| CHEMBL184321 | — | — | 1 | 4.54 |
| CHEMBL183108 | — | — | 1 | 4.50 |
| CHEMBL186869 | — | — | 1 | 4.47 |
| CHEMBL184763 | — | — | 1 | 4.46 |
| CHEMBL360423 | — | — | 1 | 4.46 |
| CHEMBL188015 | — | — | 1 | 4.46 |
| CHEMBL184518 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186296 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL363014 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL366110 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL184322 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL363221 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL184097 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL185377 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL186556 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL187011 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL187036 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL184261 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL185422 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL184208 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL365897 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL185122 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL184675 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL434543 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL187026 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL187070 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL185303 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL360433 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL184517 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL186587 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL184321 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL183108 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL186869 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL360423 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL188015 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL184763 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL184518 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL187166 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL184079 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL360203 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL184239 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL183634 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL184225 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL366330 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL186711 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL184096 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL184229 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL188070 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL186982 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL187332 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL184710 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL187218 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL187078 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL187134 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL187533 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL364205 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL187241 | — | IC50 | > | 200000.0 | nM | - |