Compound Detail
CHEMBL186901
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL186901 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PIXFHJDLMZCCNO-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
333.4
MW (Da)
2.66
ALogP
4
HBA
3
HBD
83.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C beta type CHEMBL3045 | IC50 | 6.13 | 6.1267 | 747.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C beta type | IC50 | = | 747.0 | nM | 6.13 | Inhibitory concentration against recombinant human Protein kinase C beta 2 | 15380221 |
| Protein kinase C beta type | IC50 | = | 747.0 | nM | 6.13 | Inhibition of PKCbeta2 (unknown origin) | - |
| Protein kinase C beta type | IC50 | = | 758.58 | nM | 6.12 | Inhibition of PKCbeta2 (unknown origin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-010-9439-6 | Protein kinase C beta type | 2 |
| 15380221 | 10.1016/j.bmcl.2004.07.061 | Protein kinase C beta type | 1 |
Data from ChEMBL 36 via Core Engine