Compound Detail
CHEMBL187088
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Basic Information
| ChEMBL ID | CHEMBL187088 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APKCLOROFKYTEM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
389.5
MW (Da)
2.10
ALogP
5
HBA
1
HBD
61.9
PSA (Ų)
0.79
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 7.12 | 7.12 | 75.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 75.0 | nM | 7.12 | Binding affinity towards rat 5-HT7 receptor expressed in HEK cells | 15481983 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15481983 | 10.1021/jm049743b | 5-hydroxytryptamine receptor 7 | 2 |
| 15481983 | 10.1021/jm049743b | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine