Assay Detail
Binding
CHEMBL839951
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Binding affinity towards rat 5-HT7 receptor expressed in HEK cells
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.23 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282199 | — | — | 1 | 9.00 |
| CHEMBL428892 | — | — | 1 | 9.00 |
| CHEMBL12624 | SB-258741 | — | 1 | 8.52 |
| CHEMBL3085301 | — | — | 1 | 8.40 |
| CHEMBL94984 | — | — | 1 | 8.00 |
| CHEMBL187764 | — | — | 1 | 7.96 |
| CHEMBL364124 | — | — | 1 | 7.72 |
| CHEMBL184310 | — | — | 1 | 7.72 |
| CHEMBL3085300 | — | — | 1 | 7.68 |
| CHEMBL185762 | — | — | 1 | 7.28 |
| CHEMBL188876 | — | — | 1 | 7.27 |
| CHEMBL364795 | — | — | 1 | 7.12 |
| CHEMBL187088 | — | — | 1 | 7.12 |
| CHEMBL427518 | — | — | 1 | 7.00 |
| CHEMBL364557 | — | — | 1 | 6.44 |
| CHEMBL360382 | — | — | 1 | 6.41 |
| CHEMBL359538 | — | — | 1 | 6.28 |
| CHEMBL188036 | — | — | 1 | 6.25 |
| CHEMBL366081 | — | — | 1 | 5.96 |
| CHEMBL2051975 | — | — | 2 | 5.96 |
| CHEMBL7220 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282199 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL428892 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL12624 | SB-258741 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3085301 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL94984 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL187764 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL364124 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL184310 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3085300 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL185762 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL188876 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL187088 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL364795 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL427518 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL364557 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL360382 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL359538 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL188036 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL366081 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2051975 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL7220 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL2051975 | — | Ki | = | 1180.0 | nM | 5.93 |