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Compound Detail

CHEMBL366081

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COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1

Basic Information

ChEMBL ID CHEMBL366081
Phase Preclinical
Structure Type MOL
InChI Key ALXBTSBMBMBYHQ-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

318.4
MW (Da)
4.47
ALogP
2
HBA
1
HBD
28.3
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H22N2O
MW 318.42
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -0.61

Activity Summary

Ki 3 meas. best 7.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
Ki 7.2 7.2 62.7 1
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 6.86 6.86 139.0 1
5-hydroxytryptamine receptor 7
CHEMBL3223
Ki 5.96 5.96 1100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20485427 10.1038/nature09107 Plasmodium falciparum 4
15481983 10.1021/jm049743b 5-hydroxytryptamine receptor 7 2
15481983 10.1021/jm049743b No relevant target 2
20485427 10.1038/nature09107 Unchecked 1
20485427 10.1038/nature09107 HepG2 1
- 10.6019/CHEMBL3433997 Solute carrier family 2, facilitated glucose transporter member 1 1
- 10.6019/CHEMBL3433997 Hexose transporter 1 1
- 10.6019/CHEMBL3433997 Glucose transporter 1
31357129 10.1016/j.ejmech.2019.07.050 D(2) dopamine receptor 1
31357129 10.1016/j.ejmech.2019.07.050 5-hydroxytryptamine receptor 1A 1
31357129 10.1016/j.ejmech.2019.07.050 5-hydroxytryptamine receptor 2A 1

Data from ChEMBL 36 via Core Engine