Compound Detail
CHEMBL1881194
NORFLURAZONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1881194 |
| Name | NORFLURAZONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVGOPFQZYCNLDU-UHFFFAOYSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
303.7
MW (Da)
2.95
ALogP
4
HBA
1
HBD
46.9
PSA (Ų)
0.93
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 15-cis-phytoene desaturase CHEMBL2366472 | IC50 | 7.54 | 7.52 | 29.0 | 2 |
| Scenedesmus acutus CHEMBL2367199 | IC50 | 6.73 | 6.6967 | 186.2 | 3 |
| Nicotiana tabacum CHEMBL613059 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 15-cis-phytoene desaturase | IC50 | = | 29.0 | nM | 7.54 | Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichi... | 12720390 |
| 15-cis-phytoene desaturase | IC50 | = | 31.62 | nM | 7.5 | Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichi... | 12720390 |
| Scenedesmus acutus | IC50 | = | 186.21 | nM | 6.73 | Phytotoxic activity against Scenedesmus acutus assessed as decrease in chlorophy... | - |
| Scenedesmus acutus | IC50 | = | 208.93 | nM | 6.68 | Phytotoxic activity against Scenedesmus acutus assessed as growth inhibition mea... | - |
| Scenedesmus acutus | IC50 | = | 208.93 | nM | 6.68 | Phytotoxic activity against Scenedesmus acutus assessed as inhibition of caroten... | - |
| Nicotiana tabacum | IC50 | = | 330.0 | nM | 6.48 | Inhibition of colored carotenoid formation in Nicotiana tabacum (tobacco) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14969546 | 10.1021/jf035026z | Glycine max | 8 |
| - | 10.1584/jpestics.21.473 | Unchecked | 6 |
| - | 10.1584/jpestics.27.272 | Scenedesmus acutus | 4 |
| - | 10.1016/j.cropro.2008.08.012 | Erigeron canadensis | 3 |
| 21970768 | 10.1021/jf203383s | Digitaria sanguinalis | 2 |
| 21970768 | 10.1021/jf203383s | Stellaria media | 2 |
| 21970768 | 10.1021/jf203383s | Lolium perenne | 2 |
| 21970768 | 10.1021/jf203383s | Amaranthus retroflexus | 2 |
| 12720390 | 10.1021/jf0262413 | 15-cis-phytoene desaturase | 2 |
| 11714315 | 10.1021/jf0106751 | 15-cis-phytoene desaturase | 2 |
| - | 10.1584/jpestics.21.473 | Nicotiana tabacum | 2 |
| 21970768 | 10.1021/jf203383s | Poa annua | 1 |
| 21970768 | 10.1021/jf203383s | Arabidopsis thaliana | 1 |
| - | 10.1016/j.cropro.2008.08.012 | Gossypium hirsutum | 1 |
| 12720390 | 10.1021/jf0262413 | Zeta-carotene desaturase, chloroplastic/chromoplastic | 1 |
| 11714315 | 10.1021/jf0106751 | Phytoene desaturase | 1 |
Data from ChEMBL 36 via Core Engine