Compound Detail
CHEMBL190286
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21
Basic Information
| ChEMBL ID | CHEMBL190286 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NEVPJUIOLYRWJO-VYOKSUKLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
599.7
MW (Da)
-0.18
ALogP
8
HBA
6
HBD
185.6
PSA (Ų)
0.21
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-2 angiotensin II receptor CHEMBL4607 | Ki | 8.43 | 8.43 | 3.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-2 angiotensin II receptor | Ki | = | 3.7 | nM | 8.43 | Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (... | 15537355 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15537355 | 10.1021/jm049651m | Angiotensin II receptor (AT-1) type-1 | 1 |
| 15537355 | 10.1021/jm049651m | Type-2 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine