Compound Detail
CHEMBL190293
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Basic Information
| ChEMBL ID | CHEMBL190293 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GQYUAQOQXZRNIN-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
451.6
MW (Da)
4.04
ALogP
5
HBA
3
HBD
91.2
PSA (Ų)
0.26
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.7
Ki 1 meas. best 6.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL5102 | Ki | 6.03 | 6.03 | 926.0 | 1 |
| Transient receptor potential cation channel subfamily V member 1 CHEMBL5102 | EC50 | 5.7 | 5.7 | 2000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Ki | = | 926.0 | nM | 6.03 | In vitro inhibition of [3H]RTX binding to rat TRPV1 expressed in CHO cells | 15993063 |
| Transient receptor potential cation channel subfamily V member 1 | EC50 | = | 2000.0 | nM | 5.7 | Induction of [Ca2+] uptake in CHO cells expressing rat TRPV1 relative to 300 nM ... | 15993063 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15993063 | 10.1016/j.bmcl.2005.06.006 | Transient receptor potential cation channel subfamily V member 1 | 3 |
Data from ChEMBL 36 via Core Engine