Compound Detail
CHEMBL190577
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CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1
Basic Information
| ChEMBL ID | CHEMBL190577 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NSMJSOSYBQFNAU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
553.8
MW (Da)
6.79
ALogP
7
HBA
1
HBD
90.3
PSA (Ų)
0.21
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-2 angiotensin II receptor CHEMBL4607 | Ki | 8.49 | 8.49 | 3.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-2 angiotensin II receptor | Ki | = | 3.2 | nM | 8.49 | Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT... | 15537354 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15537354 | 10.1021/jm049715t | Angiotensin II receptor (AT-1) type-1 | 1 |
| 15537354 | 10.1021/jm049715t | Type-2 angiotensin II receptor | 1 |
| 15537354 | 10.1021/jm049715t | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine