Assay Detail
Binding
CHEMBL829700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.49 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189568 | BULOXIBUTID | 0.5 | 1 | 9.40 |
| CHEMBL361927 | — | — | 1 | 9.30 |
| CHEMBL288174 | — | — | 1 | 8.55 |
| CHEMBL190577 | — | — | 1 | 8.49 |
| CHEMBL366210 | — | — | 1 | 8.40 |
| CHEMBL190811 | — | — | 1 | 8.15 |
| CHEMBL191468 | — | — | 1 | 7.16 |
| CHEMBL187871 | — | — | 1 | - |
| CHEMBL370939 | — | — | 1 | - |
| CHEMBL190796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189568 | BULOXIBUTID | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL361927 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL288174 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL190577 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL366210 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL190811 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL191468 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL187871 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL370939 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL190796 | — | Ki | > | 10000.0 | nM | - |