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Compound Detail

CHEMBL1908305

SULOPENEM
🧪 Phase III
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🧪 Phase III
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@H]3CC[S@@+]([O-])C3)S[C@H]12

Basic Information

ChEMBL ID CHEMBL1908305
Name SULOPENEM
Phase Phase III
Structure Type MOL
InChI Key FLSUCZWOEMTFAQ-PRBGKLEPSA-N

Known Names

CP-70,429 CP-70429 Sulopenem
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
3
Known Names
4
Indications
1
Mechanisms

Molecular Properties

349.5
MW (Da)
0.41
ALogP
6
HBA
2
HBD
100.9
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product
USAN Stem -penem
USAN Year 1992

Extended Properties

Molecular Formula C12H15NO5S3
MW 349.46
Aromatic Rings 0
Heavy Atoms 21
NP-Likeness 0.35

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Bacterial penicillin-binding protein inhibitor INHIBITOR Bacterial penicillin-binding protein

Indications

Infections Urinary Tract Infections Pneumonia, Bacterial Pneumonia

Literature References

PubMed DOI Target Context # Activities
19307366 10.1128/aac.01531-08 Streptococcus pneumoniae 55
19223615 10.1128/aac.01557-08 NON-PROTEIN TARGET 17
19223615 10.1128/aac.01557-08 Bacteroides fragilis 4
19223615 10.1128/aac.01557-08 Bacteroides thetaiotaomicron 4
19223615 10.1128/aac.01557-08 Eggerthella lenta 4
19223615 10.1128/aac.01557-08 Fusobacterium nucleatum 3
19223615 10.1128/aac.01557-08 Anaerococcus tetradius 3
19223615 10.1128/aac.01557-08 Fusobacterium mortiferum 3
19223615 10.1128/aac.01557-08 Fusobacterium varium 3
19223615 10.1128/aac.01557-08 Finegoldia magna 3
19223615 10.1128/aac.01557-08 Prevotella nigrescens 3
19223615 10.1128/aac.01557-08 Parvimonas micra 3
19223615 10.1128/aac.01557-08 Prevotella intermedia 3
19223615 10.1128/aac.01557-08 Prevotella denticola 3
19223615 10.1128/aac.01557-08 Prevotella melaninogenica 3
19223615 10.1128/aac.01557-08 Prevotella buccae 3
19223615 10.1128/aac.01557-08 Prevotella bivia 3
19223615 10.1128/aac.01557-08 Parabacteroides distasonis 3
19223615 10.1128/aac.01557-08 Phocaeicola vulgatus 3
19223615 10.1128/aac.01557-08 Bacteroides ovatus 3

Data from ChEMBL 36 via Core Engine