Compound Detail
CHEMBL190899
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL190899 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOURTTOYLTUYKY-LLVKDONJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
235.3
MW (Da)
2.67
ALogP
2
HBA
1
HBD
38.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-8 receptors, CXCR1/CXCR2 CHEMBL2096909 | IC50 | 8.74 | 8.74 | 1.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-8 receptors, CXCR1/CXCR2 | IC50 | = | 1.8 | nM | 8.74 | Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | 15974585 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15974585 | 10.1021/jm049082i | Interleukin-8 receptors, CXCR1/CXCR2 | 2 |
| 15974585 | 10.1021/jm049082i | Prostaglandin G/H synthase (cyclooxygenase) | 1 |
Data from ChEMBL 36 via Core Engine