Assay Detail
Functional
CHEMBL833397
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Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Interleukin-8 receptors, CXCR1/CXCR2 (CHEMBL2096909) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.55 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190899 | — | — | 1 | 8.74 |
| CHEMBL191413 | REPARIXIN | 3.0 | 1 | 8.28 |
| CHEMBL372052 | R-KETOPROFEN | — | 1 | 7.47 |
| CHEMBL75435 | DEXKETOPROFEN | 4.0 | 1 | 7.30 |
| CHEMBL192943 | — | — | 1 | 7.10 |
| CHEMBL175 | DEXIBUPROFEN | 4.0 | 1 | 7.00 |
| CHEMBL427526 | (R)-IBUPROPHEN | 1.0 | 1 | 6.96 |
| CHEMBL365276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190899 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL191413 | REPARIXIN | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL372052 | R-KETOPROFEN | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL75435 | DEXKETOPROFEN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL192943 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL175 | DEXIBUPROFEN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL427526 | (R)-IBUPROPHEN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL365276 | — | IC50 | - | nM | - |