Compound Detail
CHEMBL372052
R-KETOPROFEN Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL372052 |
| Name | R-KETOPROFEN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DKYWVDODHFEZIM-LLVKDONJSA-N |
2
Targets
2
Activities
1
Assay Types
3
PK Parameters
10
Publications
0
Known Names
Molecular Properties
254.3
MW (Da)
3.11
ALogP
2
HBA
1
HBD
54.4
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-8 CHEMBL2157 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Interleukin-8 receptors, CXCR1/CXCR2 CHEMBL2096909 | IC50 | 7.47 | 7.47 | 34.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 21.3 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| F | 85.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-8 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pret... | 19560921 |
| Interleukin-8 receptors, CXCR1/CXCR2 | IC50 | = | 34.0 | nM | 7.47 | Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | 15974585 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15974585 | 10.1021/jm049082i | Interleukin-8 receptors, CXCR1/CXCR2 | 2 |
| 17665889 | 10.1021/jm061469t | Unchecked | 2 |
| - | 10.6019/CHEMBL3301361 | ADMET | 2 |
| 15974585 | 10.1021/jm049082i | Prostaglandin G/H synthase (cyclooxygenase) | 1 |
| 17870541 | 10.1016/j.bmc.2007.08.060 | Homo sapiens | 1 |
| 19560921 | 10.1016/j.bmcl.2009.06.027 | L1.2 | 1 |
| 19560921 | 10.1016/j.bmcl.2009.06.027 | ADMET | 1 |
| 19560921 | 10.1016/j.bmcl.2009.06.027 | Interleukin-8 | 1 |
| 21615150 | 10.1021/jm200371q | C-X-C chemokine receptor type 1 | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine