Compound Detail
CHEMBL1910380
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Basic Information
| ChEMBL ID | CHEMBL1910380 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GREREVYRUNFCTM-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
3.43
ALogP
6
HBA
1
HBD
77.6
PSA (Ų)
0.43
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.22
Kd 1 meas. best 8.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL3943 | Kd | 8.14 | 8.14 | 7.2 | 1 |
| Histamine H1 receptor CHEMBL231 | Ki | 6.22 | 6.22 | 602.6 | 1 |
| Histamine H4 receptor CHEMBL3759 | Ki | 4.65 | 4.65 | 22387.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | Kd | = | 7.244 | nM | 8.14 | Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histami... | 21944853 |
| Histamine H1 receptor | Ki | = | 602.56 | nM | 6.22 | Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressi... | 21944853 |
| Histamine H4 receptor | Ki | = | 22387.21 | nM | 4.65 | Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressin... | 21944853 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21944853 | 10.1016/j.bmcl.2011.09.001 | Histamine H1 receptor | 3 |
| 21944853 | 10.1016/j.bmcl.2011.09.001 | Histamine H4 receptor | 1 |
Data from ChEMBL 36 via Core Engine