Compound Detail
CHEMBL1910840
KALOPANAXSAPONIN B Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1910840 |
| Name | KALOPANAXSAPONIN B |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RYHDIBJJJRNDSX-MCGLQMIESA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
1221.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.0
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| No relevant target CHEMBL2362975 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 800.0 | nM | 6.1 | Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1... | 21870831 |
| No relevant target | EC50 | = | 10000.0 | nM | 5.0 | Reduction in surface tension in 0.1 M PBS after 10 mins by Wilhelmy plate method... | 22503361 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24084294 | 10.1016/j.bmc.2013.09.008 | ECV-304 | 4 |
| 21870831 | 10.1021/np200382s | Unchecked | 3 |
| 22503361 | 10.1016/j.bmc.2012.03.032 | ECV-304 | 2 |
| 22503361 | 10.1016/j.bmc.2012.03.032 | No relevant target | 2 |
| 30808589 | 10.1016/j.bmcl.2019.02.022 | RAW264.7 | 2 |
| 21870831 | 10.1021/np200382s | HepG2 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 27400231 | 10.1021/acs.jnatprod.6b00329 | Cortical neurone | 1 |
| 31301930 | 10.1016/j.bmcl.2019.07.010 | RAW264.7 | 1 |
| 33131725 | 10.1016/j.ejmech.2020.112932 | AMP-activated protein kinase, AMPK | 1 |
| 37453188 | 10.1016/j.bmc.2023.117408 | Jurkat | 1 |
| 37453188 | 10.1016/j.bmc.2023.117408 | MT2 | 1 |
Data from ChEMBL 36 via Core Engine