Assay Detail
Binding
CHEMBL1913573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.38 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910842 | SIEBOLDIANOSIDE A | — | 1 | 6.22 |
| CHEMBL1910840 | KALOPANAXSAPONIN B | — | 1 | 6.10 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 6.05 |
| CHEMBL1910839 | — | — | 1 | 5.85 |
| CHEMBL1910841 | KALOPANAXSAPONIN C | — | 1 | 5.41 |
| CHEMBL447565 | ALPHA-HEDERIN | — | 1 | 5.26 |
| CHEMBL1910844 | DIPSACUSSAPONIN A | — | 1 | 5.21 |
| CHEMBL1910833 | — | — | 1 | 5.19 |
| CHEMBL1910836 | — | — | 1 | 5.05 |
| CHEMBL1910843 | — | — | 1 | 5.04 |
| CHEMBL538919 | CAULOSIDE D | — | 1 | 5.04 |
| CHEMBL1910834 | — | — | 1 | 5.03 |
| CHEMBL1910837 | — | — | 1 | 5.03 |
| CHEMBL1910835 | — | — | 1 | 4.79 |
| CHEMBL1910838 | NIPPONOGENIN E | — | 1 | - |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910842 | SIEBOLDIANOSIDE A | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1910840 | KALOPANAXSAPONIN B | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1910839 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1910841 | KALOPANAXSAPONIN C | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL447565 | ALPHA-HEDERIN | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1910844 | DIPSACUSSAPONIN A | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1910833 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1910836 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1910843 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL538919 | CAULOSIDE D | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1910834 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1910837 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1910835 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1910838 | NIPPONOGENIN E | IC50 | > | 20000.0 | nM | - |
| CHEMBL486400 | HEDERAGENIN | IC50 | > | 20000.0 | nM | - |