Compound Detail
CHEMBL538919
CAULOSIDE D Enter ChEMBL ID:
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C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC(=O)[C@]45CCC(C)(C)C[C@H]4C4=CC[C@@H]6[C@@]7(C)CC[C@H](O[C@@H]8OC[C@H](O)[C@H](O)[C@H]8O)[C@@](C)(CO)[C@@H]7CC[C@@]6(C)[C@]4(C)CC5)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O
Basic Information
| ChEMBL ID | CHEMBL538919 |
| Name | CAULOSIDE D |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UEHILKCNLIKLEV-LXABABOZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
1075.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.43
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 3680.0 | nM | 5.43 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-... | 31301930 |
| Unchecked | IC50 | = | 9200.0 | nM | 5.04 | Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1... | 21870831 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21870831 | 10.1021/np200382s | Unchecked | 3 |
| 31301930 | 10.1016/j.bmcl.2019.07.010 | RAW264.7 | 2 |
| 30808589 | 10.1016/j.bmcl.2019.02.022 | RAW264.7 | 2 |
| 19449879 | 10.1021/np900164b | HL-60 | 1 |
| 20540535 | 10.1021/np100057y | Prostaglandin G/H synthase 2 | 1 |
| 20540535 | 10.1021/np100057y | Prostaglandin G/H synthase 1 | 1 |
| 21870831 | 10.1021/np200382s | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine