Assay Detail
Functional
CHEMBL4390549
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive triterpene glycosides from the fruit of Stauntonia hexaphylla and insights into the molecular mechanism of its inflammatory effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.00 |
| CHEMBL447565 | ALPHA-HEDERIN | — | 1 | 5.96 |
| CHEMBL502407 | — | — | 1 | 5.89 |
| CHEMBL2391929 | — | — | 1 | 5.82 |
| CHEMBL452911 | — | — | 1 | 5.65 |
| CHEMBL4453174 | — | — | 1 | 5.51 |
| CHEMBL538919 | CAULOSIDE D | — | 1 | 5.43 |
| CHEMBL444982 | — | — | 1 | 5.40 |
| CHEMBL4583205 | — | — | 1 | 5.38 |
| CHEMBL455747 | Hederagenin-3-O-beta-D-glucopyranoside | — | 1 | 4.87 |
| CHEMBL464466 | ARJUNOLIC ACID | — | 1 | 4.82 |
| CHEMBL4562676 | — | — | 1 | - |
| CHEMBL540943 | KIZUTA CIRENSENOSIDE O SAPONIN K3 | — | 1 | - |
| CHEMBL4552174 | — | — | 1 | - |
| CHEMBL464406 | LEONURISIDE | — | 1 | - |
| CHEMBL506880 | HEDERASAPONIN B | — | 1 | - |
| CHEMBL1910840 | KALOPANAXSAPONIN B | — | 1 | - |
| CHEMBL4521246 | — | — | 1 | - |
| CHEMBL562662 | — | — | 1 | - |
| CHEMBL4436386 | — | — | 1 | - |
| CHEMBL4440658 | — | — | 1 | - |
| CHEMBL4538698 | — | — | 1 | - |
| CHEMBL4562613 | — | — | 1 | - |
| CHEMBL4451307 | — | — | 1 | - |
| CHEMBL4451871 | — | — | 1 | - |
| CHEMBL387842 | DIHYDROFERULIC ACID | — | 1 | - |
| CHEMBL4577875 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL447565 | ALPHA-HEDERIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL502407 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2391929 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL452911 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4453174 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL538919 | CAULOSIDE D | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL444982 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4583205 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL455747 | Hederagenin-3-O-beta-D-glucopyranoside | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL464466 | ARJUNOLIC ACID | IC50 | = | 15170.0 | nM | 4.82 |
| CHEMBL4562676 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL540943 | KIZUTA CIRENSENOSIDE O SAPONIN K3 | IC50 | > | 50000.0 | nM | - |
| CHEMBL4552174 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL464406 | LEONURISIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL506880 | HEDERASAPONIN B | IC50 | > | 50000.0 | nM | - |
| CHEMBL1910840 | KALOPANAXSAPONIN B | IC50 | > | 50000.0 | nM | - |
| CHEMBL4521246 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL562662 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4436386 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4440658 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4538698 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4562613 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4451307 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4451871 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL387842 | DIHYDROFERULIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL4577875 | — | IC50 | > | 50000.0 | nM | - |