Compound Detail
CHEMBL1911013
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Basic Information
| ChEMBL ID | CHEMBL1911013 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RWTPCDKVABLMHM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
442.4
MW (Da)
1.69
ALogP
10
HBA
0
HBD
105.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL2499 | IC50 | 7.21 | 7.21 | 61.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.18 | 7.18 | 66.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 61.0 | nM | 7.21 | Inhibition of mouse recombinant PI3K p110alpha expressed in Sf21 insect cells us... | 21882832 |
| Unchecked | IC50 | = | 66.0 | nM | 7.18 | Inhibition of bovine recombinant PI3K p110delta expressed in Sf21 insect cells u... | 21882832 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21882832 | 10.1021/jm200688y | NON-PROTEIN TARGET | 2 |
| 21882832 | 10.1021/jm200688y | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 21882832 | 10.1021/jm200688y | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
| 21882832 | 10.1021/jm200688y | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine