Assay Detail
Binding
CHEMBL1914127
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Inhibition of bovine recombinant PI3K p110delta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimaging
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.60 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910998 | — | — | 1 | 9.57 |
| CHEMBL1911122 | — | — | 1 | 9.57 |
| CHEMBL1911114 | — | — | 1 | 9.52 |
| CHEMBL1911117 | — | — | 1 | 9.42 |
| CHEMBL1911118 | — | — | 1 | 9.28 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 9.15 |
| CHEMBL1911005 | — | — | 1 | 9.07 |
| CHEMBL1911115 | — | — | 1 | 8.74 |
| CHEMBL1910999 | — | — | 1 | 8.41 |
| CHEMBL1911000 | — | — | 1 | 8.26 |
| CHEMBL1911119 | — | — | 1 | 8.17 |
| CHEMBL1911002 | — | — | 1 | 8.13 |
| CHEMBL1911121 | — | — | 1 | 8.00 |
| CHEMBL1911008 | — | — | 1 | 7.92 |
| CHEMBL1911116 | — | — | 1 | 7.90 |
| CHEMBL1911124 | — | — | 1 | 7.89 |
| CHEMBL1910990 | — | — | 1 | 7.89 |
| CHEMBL1911125 | — | — | 1 | 7.85 |
| CHEMBL1911123 | — | — | 1 | 7.75 |
| CHEMBL1910994 | — | — | 1 | 7.46 |
| CHEMBL1910989 | — | — | 1 | 7.46 |
| CHEMBL1911014 | — | — | 1 | 7.41 |
| CHEMBL1910993 | — | — | 1 | 7.39 |
| CHEMBL1910995 | — | — | 1 | 7.27 |
| CHEMBL1911009 | — | — | 1 | 7.19 |
| CHEMBL1911013 | — | — | 1 | 7.18 |
| CHEMBL1911006 | — | — | 1 | 7.17 |
| CHEMBL1910991 | — | — | 1 | 7.16 |
| CHEMBL1910997 | — | — | 1 | 7.12 |
| CHEMBL1909655 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910998 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL1911122 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL1911114 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1911117 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1911118 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1911005 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL1911115 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1910999 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1911000 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1911119 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1911002 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL1911121 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1911008 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1911116 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL1911124 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1910990 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1911125 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1911123 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1910994 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1910989 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1911014 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1910993 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1910995 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1911009 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1911013 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1911006 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1910991 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1910997 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1909655 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1910988 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1911001 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL1911004 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1911015 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL1910996 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1911003 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1911007 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL1911011 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1911010 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1911120 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1910992 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL1911012 | — | IC50 | > | 1000.0 | nM | - |