Compound Detail
CHEMBL1911015
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Basic Information
| ChEMBL ID | CHEMBL1911015 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XZCFLSVUEQRRCU-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
477.5
MW (Da)
1.84
ALogP
11
HBA
0
HBD
99.9
PSA (Ų)
0.52
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 7.7 | 7.57 | 20.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 6.59 | 6.59 | 258.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL2499 | IC50 | 6.47 | 6.47 | 335.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform CHEMBL3145 | IC50 | 6.1 | 6.1 | 801.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 20.0 | nM | 7.7 | Antiproliferative activity against human NZB5 cells expressing wild type p110alp... | 21882832 |
| NON-PROTEIN TARGET | IC50 | = | 36.0 | nM | 7.44 | Antiproliferative activity against human NZOV9 cells expressing p110alpha kinase... | 21882832 |
| Unchecked | IC50 | = | 258.0 | nM | 6.59 | Inhibition of bovine recombinant PI3K p110delta expressed in Sf21 insect cells u... | 21882832 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 335.0 | nM | 6.47 | Inhibition of mouse recombinant PI3K p110alpha expressed in Sf21 insect cells us... | 21882832 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | IC50 | = | 801.0 | nM | 6.1 | Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells usi... | 21882832 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21882832 | 10.1021/jm200688y | NON-PROTEIN TARGET | 2 |
| 21882832 | 10.1021/jm200688y | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 21882832 | 10.1021/jm200688y | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
| 21882832 | 10.1021/jm200688y | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine