Assay Detail
Binding
CHEMBL1914128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimaging
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.10 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910998 | — | — | 1 | 9.17 |
| CHEMBL1911122 | — | — | 1 | 9.09 |
| CHEMBL1911118 | — | — | 1 | 9.04 |
| CHEMBL1911117 | — | — | 1 | 8.85 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.32 |
| CHEMBL1911114 | — | — | 1 | 8.17 |
| CHEMBL1911119 | — | — | 1 | 7.73 |
| CHEMBL1910999 | — | — | 1 | 7.60 |
| CHEMBL1911123 | — | — | 1 | 7.46 |
| CHEMBL1910993 | — | — | 1 | 7.41 |
| CHEMBL1911125 | — | — | 1 | 7.40 |
| CHEMBL1911005 | — | — | 1 | 7.39 |
| CHEMBL1911014 | — | — | 1 | 7.33 |
| CHEMBL1910990 | — | — | 1 | 7.28 |
| CHEMBL1911002 | — | — | 1 | 7.25 |
| CHEMBL1911008 | — | — | 1 | 7.17 |
| CHEMBL1911121 | — | — | 1 | 7.14 |
| CHEMBL1911115 | — | — | 1 | 7.03 |
| CHEMBL1911000 | — | — | 1 | 6.98 |
| CHEMBL1911116 | — | — | 1 | 6.93 |
| CHEMBL1911124 | — | — | 1 | 6.77 |
| CHEMBL1910994 | — | — | 1 | 6.64 |
| CHEMBL1910995 | — | — | 1 | 6.60 |
| CHEMBL1910989 | — | — | 1 | 6.54 |
| CHEMBL1911009 | — | — | 1 | 6.51 |
| CHEMBL1910997 | — | — | 1 | 6.42 |
| CHEMBL1910991 | — | — | 1 | 6.34 |
| CHEMBL1911006 | — | — | 1 | 6.32 |
| CHEMBL1909655 | — | — | 1 | 6.29 |
| CHEMBL1911004 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910998 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL1911122 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1911118 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL1911117 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1911114 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1911119 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL1910999 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1911123 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1910993 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1911125 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1911005 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1911014 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1910990 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1911002 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1911008 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1911121 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1911115 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1911000 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL1911116 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1911124 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1910994 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1910995 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1910989 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL1911009 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1910997 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL1910991 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL1911006 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1909655 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL1911004 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1911015 | — | IC50 | = | 801.0 | nM | 6.10 |
| CHEMBL1911120 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1910988 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL1911003 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1911001 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1911013 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911012 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911011 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911010 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911007 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1910996 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1910992 | — | IC50 | > | 1000.0 | nM | - |