Compound Detail
CHEMBL1910992
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Basic Information
| ChEMBL ID | CHEMBL1910992 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QIKMZLIWHHGXQS-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
397.4
MW (Da)
0.38
ALogP
10
HBA
1
HBD
101.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 6.12 | 5.69 | 750.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.26 | 5.26 | 5470.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 750.0 | nM | 6.12 | Antiproliferative activity against human NZB5 cells expressing wild type p110alp... | 21882832 |
| Unchecked | IC50 | = | 5470.0 | nM | 5.26 | Inhibition of bovine recombinant PI3K p110delta expressed in Sf21 insect cells u... | 21882832 |
| NON-PROTEIN TARGET | IC50 | = | 5500.0 | nM | 5.26 | Antiproliferative activity against human NZOV9 cells expressing p110alpha kinase... | 21882832 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21882832 | 10.1021/jm200688y | NON-PROTEIN TARGET | 2 |
| 21882832 | 10.1021/jm200688y | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 21882832 | 10.1021/jm200688y | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
| 21882832 | 10.1021/jm200688y | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine