Compound Detail
CHEMBL1911159
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CC(C)(C(=O)Nc1nncs1)[C@H]1c2ccccc2Oc2nc(-c3ccc(C(=O)O)cc3)ccc21
Basic Information
| ChEMBL ID | CHEMBL1911159 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WTOAAUGTOXEPOY-FQEVSTJZSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
472.5
MW (Da)
5.20
ALogP
7
HBA
2
HBD
114.3
PSA (Ų)
0.41
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.26
Ki 1 meas. best 7.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | Ki | 7.81 | 7.81 | 15.4 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 6.26 | 6.11 | 544.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Ki | = | 15.4 | nM | 7.81 | Displacement of GS-red from glucocorticoid receptor by fluorescence polarization... | 21899328 |
| Glucocorticoid receptor | EC50 | = | 544.0 | nM | 6.26 | Transrepression activity at glucocorticoid receptor alpha in phorbol myristate a... | 21899328 |
| Glucocorticoid receptor | EC50 | = | 1086.0 | nM | 5.96 | Transrepression activity at glucocorticoid receptor alpha in IL-1beta-stimulated... | 21899328 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21899328 | 10.1021/jm200879j | Glucocorticoid receptor | 9 |
Data from ChEMBL 36 via Core Engine