Compound Detail
CHEMBL1915742
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Basic Information
| ChEMBL ID | CHEMBL1915742 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IWHSMTDCHWZUDR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
404.4
MW (Da)
4.56
ALogP
6
HBA
0
HBD
62.1
PSA (Ų)
0.43
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL6140 | IC50 | 8.5 | 8.5 | 3.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | IC50 | = | 3.162 | nM | 8.5 | Inhibition of rat recombinant PDE10A expressed in baculovirus infected insect Sf... | 21777010 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21777010 | 10.1021/jm200536d | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 1 |
Data from ChEMBL 36 via Core Engine