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Compound Detail

CHEMBL1923541

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CCCCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)N[C@@H](CO)C(=O)O)OC(=O)CCCCCCCCCCCCC

Basic Information

ChEMBL ID CHEMBL1923541
Phase Preclinical
Structure Type MOL
InChI Key ZWXWXCXNGRNHTA-CEUYOYMZSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

703.0
MW (Da)
7.47
ALogP
9
HBA
4
HBD
165.2
PSA (Ų)
0.04
QED
2
Ro5 Violations
35
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H70N2O8S
MW 703.04
Aromatic Rings 0
Heavy Atoms 48
NP-Likeness 0.44

Activity Summary

EC50 1 meas. best 9.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 2
CHEMBL4163
EC50 9.25 9.25 0.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Toll-like receptor 2 EC50 = 0.56 nM 9.25 Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB i... 22007676

Literature References

PubMed DOI Target Context # Activities
22007676 10.1021/jm201071e Toll-like receptor 2 1

Data from ChEMBL 36 via Core Engine