Assay Detail
Functional
CHEMBL1926410
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Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectrophotometric analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 8.85 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1923557 | — | — | 1 | 9.59 |
| CHEMBL1923536 | — | — | 1 | 9.35 |
| CHEMBL1923541 | — | — | 1 | 9.25 |
| CHEMBL1923538 | — | — | 1 | 9.06 |
| CHEMBL1923537 | — | — | 1 | 9.00 |
| CHEMBL1923542 | — | — | 1 | 8.83 |
| CHEMBL1923545 | — | — | 1 | 8.81 |
| CHEMBL1923548 | — | — | 1 | 8.73 |
| CHEMBL1923547 | — | — | 1 | 8.71 |
| CHEMBL1923544 | — | — | 1 | 8.68 |
| CHEMBL1923546 | — | — | 1 | 8.49 |
| CHEMBL1923549 | — | — | 1 | 8.35 |
| CHEMBL1923540 | — | — | 1 | 8.19 |
| CHEMBL1923543 | — | — | 1 | - |
| CHEMBL1923550 | — | — | 1 | - |
| CHEMBL1923551 | — | — | 1 | - |
| CHEMBL1923552 | — | — | 1 | - |
| CHEMBL1923553 | — | — | 1 | - |
| CHEMBL1923554 | — | — | 1 | - |
| CHEMBL1923555 | — | — | 1 | - |
| CHEMBL1923556 | — | — | 1 | - |
| CHEMBL1923539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1923557 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL1923536 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL1923541 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1923538 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL1923537 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1923542 | — | EC50 | = | 1.47 | nM | 8.83 |
| CHEMBL1923545 | — | EC50 | = | 1.55 | nM | 8.81 |
| CHEMBL1923548 | — | EC50 | = | 1.86 | nM | 8.73 |
| CHEMBL1923547 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL1923544 | — | EC50 | = | 2.11 | nM | 8.68 |
| CHEMBL1923546 | — | EC50 | = | 3.23 | nM | 8.49 |
| CHEMBL1923549 | — | EC50 | = | 4.44 | nM | 8.35 |
| CHEMBL1923540 | — | EC50 | = | 6.48 | nM | 8.19 |
| CHEMBL1923543 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923550 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923551 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923552 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923553 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923554 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923555 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923556 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1923539 | — | EC50 | > | 1000.0 | nM | - |