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Compound Detail

CHEMBL1923548

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CCCCCCCCCCCCCCCC(=O)O[C@H](CO)CSC[C@H](N)C(=O)N[C@@H](CO)C(=O)O

Basic Information

ChEMBL ID CHEMBL1923548
Phase Preclinical
Structure Type MOL
InChI Key BKWASELTCRREJK-FSSWDIPSSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

520.7
MW (Da)
2.99
ALogP
8
HBA
5
HBD
159.2
PSA (Ų)
0.10
QED
1
Ro5 Violations
24
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H48N2O7S
MW 520.73
Aromatic Rings 0
Heavy Atoms 35
NP-Likeness 0.60

Activity Summary

EC50 1 meas. best 8.73

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 2
CHEMBL4163
EC50 8.73 8.73 1.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Toll-like receptor 2 EC50 = 1.86 nM 8.73 Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB i... 22007676

Literature References

PubMed DOI Target Context # Activities
22007676 10.1021/jm201071e Toll-like receptor 2 1

Data from ChEMBL 36 via Core Engine