Compound Detail
CHEMBL1923592
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C[C@H](O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2)CC1
Basic Information
| ChEMBL ID | CHEMBL1923592 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QSAUPKPUCQZYSW-FQEVSTJZSA-N |
1
Targets
1
Activities
1
Assay Types
4
PK Parameters
3
Publications
0
Known Names
Molecular Properties
534.7
MW (Da)
4.10
ALogP
8
HBA
2
HBD
103.1
PSA (Ų)
0.35
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 9.05 | 9.05 | 0.9 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.4833 | hr | Mus musculus |
| T1/2 | 0.3 | hr | Rattus norvegicus |
| T1/2 | 0.6667 | hr | Canis lupus familiaris |
| T1/2 | 0.08333 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | IC50 | = | 0.9 | nM | 9.05 | Inhibition of human recombinant JAK2 using biotinyl-amino-hexanoyl-EQEDEPEGDYFEW... | 22041060 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22041060 | 10.1016/j.bmcl.2011.10.032 | Liver microsomes | 3 |
| 22041060 | 10.1016/j.bmcl.2011.10.032 | Liver | 2 |
| 22041060 | 10.1016/j.bmcl.2011.10.032 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine