Compound Detail
CHEMBL1929214
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Basic Information
| ChEMBL ID | CHEMBL1929214 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WDVYMIJZYQKAKJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
453.6
MW (Da)
6.03
ALogP
4
HBA
2
HBD
61.4
PSA (Ų)
0.51
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 su... | 22014550 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22014550 | 10.1016/j.bmcl.2011.09.078 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine